THE BIOLOGICAL ACTIVITY OF POLYMER SILVER-CONTAINING NANOCOMPOSITES

A new water-soluble polymer nanocomposite containing silver nanoparticles with a size of 1-6 nm was syn-thesized by the chemical recovery of silver ions in a copolymer matrix based on 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone. The biological activity of the synthesized compound was investigated. It is established that the nanocomposite exhibits a high antimicrobial activity against such gram-positive and gram-negative microorganisms as Escherichia coli АТСС 25922, Pseudomonas aeruginosa ATCC 27853, Klebsiella АТСС 700603 (ESBL), Staphylococcus aureus ATCC 25923, Enterococcus faecalis АТСС 29212. For this nano-composite, the values of the minimum inhibiting and bactericidal concentrations that suppress the growth of the aforementioned microorganisms are shown to vary within a range of 0.5-8 µg/ml and 0.5-16 µg/ml, re-spectively. The results show that the synthesized nanocomposite can be successfully used for the devel-opment of effective antimicrobial and antiseptic pharmaceutical preparations aimed at the prevention and treatment of dangerous diseases.