Dysregulation of microRNA-500 expression in development process from hepatitis C liver cirrhosis to liver cancer

Objective To investigate the dysregulation of microRNA-500 (miR-500) in the development process from hepatitis C liver cirrhosis to hepatocellular carcinoma so as to clarify the role of change of miR-500 expression in the development process from the hepatitis C to liver cirrhosis and hepatocellular carcinoma.Methods From Nov.2012 to Oct.2013,8 cases of hepatitis C liver cirrhosis and 8 cases of hepatitis C virus infection-related liver cancer were selected as the research objects,and 8 cases of the healthy check-up served as the control group.The expression level of miR-500 in the plasma of the above three groups was tested by using real-time quantitative polymerase chain reaction (Real-time PCR).Results The expression level of miR-500 in liver cirrhosis group was 5.72 ± 2.28,higher than 0.95 ± 0.48 in the control group,and that in liver cancer group was 18.62 ± 8.13,higher than in the control group and liver cirrhosis group.Conclusion The miR-500 may be involved in the development process from chronic hepatitis C liver cirrhosis to liver cancer. Key words: MicroRNA-500;  Hepatitis C virus;  Liver cirrhosis;  Hepatitis C virus related liver cancer