Supernumerary ring chromosomes accompanied with near-tetraploidy following chemotherapy and cranial radiation in a girl with a relapsed acute lymphoblastic leukemia

Supernumerary ring chromosomes of different sizes and near-tetraploidy were presented in the bone marrow cells of 12-year-old girl with relapsed acute lymphoblastic leukemia who had been treated previously with chemotherapy and cranial radiation. Despite significant chromosomal abnormalities, complete hematologic and cytogenetic remissions were achieved.