2,3-substituted indazole or 4,5,6,7-tetrahydro-indazoles as FXR modulators and against diseases associated diislipidemia

Compounds of the formula wherein R1 is selected from the group consisting of phenyl, naphthyl and heteroaryl ring, said ring is unsubstituted O- 1-3 substituents independently selected from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenoalkoxy and cyano; R2, R3, R4 and R5 each independently are selected from the group consisting of hydrogen, halogen or alquiloinferior; R2 'and R3' together and also R4 'and R5' together are replaced by a double bond, or R2 ', R3', R4 'and R5' are hydrogen; R6 is selected from the group consisting of hydrogen, methyl, ethyl, hydroxy, methoxy, fluoro, fluoromethyl, difluoromethyl ytrifluormetilo; R7 is selected from the group consisting of lower alkyl or cycloalkyl, lower cycloalkylalkyl, lower alkoxyalkyl, unsubstituted phenyl phenyl substituted by 1 to 3 substituents independently selected from the group formadopor lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy and cyano, lower phenylalkyl wherein phenyl is unsubstituted or substituted with 1-3 substituents selected from the group conindependencia consisting of lower alkyl and cyano, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower haloalkoxy, unsubstituted heteroaryl or heteroaryl substituted by 1 to 3 substituents independently selected from elgrupo consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy and cyano halogenoalcoxiinferior, and heterocyclyl; and R8 is selected from the group consisting of -C (O) -NH-R9, -CR11R12-OR10, -O- (CR11R12) n-R10; -CR11R12-SR10, SO2-R10 -CR11R12-, -CR11R12-NR13-R10; -CH> = CH-R10 and - (CH2) p-R10, wherein n is 0 or 1, p is 2, R9 is selected from the group consisting of lower alkyl, cycloalkyl, lower cycloalkylalkyl, cycloalkyl substituted por1-3 substituents independently selected from the group consisting of hydroxy, carboxyl, tetrazolyl, lower carboxyalkyl, (lower alkoxy), lower alkoxycarbonylalkyl, lower carboxylalkoxy yalcoxicarbonilalcoxi lower, heterocyclyl, unsubstituted phenyl and phenyl substituted with 1-3 substituents elegidoscon independence from the group consisting of lower alkyl, halogen, lower halogenalkyl, hydroxy, lower alkoxy, lower halogenalkoxy, carboxyl, tetrazolyl, (lower alkoxy) carbonyl, alcoxicarbonilalquiloinferior, lower carboxyalkyl, lower carboxylalkoxy, lower alkoxycarbonylalkoxy, cyano and cycloalkyloxy losque the cycloalkyl group is substituted by carboxyl, (lower alkoxy) alkoxycarbonyl or tetrazolyl; R10 is selected from the group consisting of lower alkyl, cycloalkyl, lower cycloalkylalkyl.