Clinical feature and drug resistance analysis of the deep fungal infection of 180 strains

【Objective】 To investigate the clinical feature,species distribution and antifungal in vitro susceptibility of deep fungal infections in Hunan People's Hospital and provide the evidence to clinical reasonable selection of antifungal drugs.【Methods】 A total of 180 clinical isolates of fungal collected consecutively between Jan 2007 and Oct 2008.Sobaurand agar was used for fungi culture.All isolates were identified to the species level by 32C identification cards.In vitro antifungal susceptibility testing of Candida was performed by ATB FUNGUS 3 Fungal susceptibility strips.【Results】 There were five major species causing fungal infection.The candida species covered most frequently was C.albicans(32.1%),followed by C.tropical is(16.0%),C.parapsilosis(11.2%),C.glabrata(7.1%),C.krusei(5.9%).The vitro antifungal susceptibility test revealed that 5-flurocytosines and amphotericin B were the most sensitive drugs(85.7%).【Conclusion】 C.albicans and C.tropical are the main pathogens causing fungal infection.Candida remains high in vitro susceptibility to 5-flurocytosines and amphotericin B.Fluconazole,itraconazole and voriconazole have different levels of drug resistance.Clinical doctors must pay attention to deep fungus detection and antimicrobial susceptibility test,according to the result is reasonable use of antifungal drugs.