OXIDATIVE STRESS PARAMETERS AND THE METABOLIC SYNDROME MANIFESTATIONS RELATIONSHIP

Objectives. Oxidative stress (OS) parameters and metabolic syndrome (MS) induced dermal manifistations relationship. Methodology. Prospective clinical study, 94 respondents. Clinical evaluation: general examination (specifically for skin changes), anthropometric measurements, blood samples (glucose, cholesterol, triglycerides, lipoproteins, C-reactive protein, Vitamin D, OS biomarkers). Skin was evaluated through dermatoscopy; structural changes and skin immunity was evaluated by immunohistochemistry of punch-bioptates. Immunohistochemistry included CD1a, CD31, CD34, CD3, CD8. Results. OS related parameters were higher among MS patients. Correlation has been identified between OS biomarker and certain skin changes (elastosis, keratosis, dispigmintation, lentigo) in patients with MS. Light microscopy revealed degeneration of dermal tissue, deposition of elastic fibers; stratum spinosum thickness positively correlated with increased OS parameters (p-value<0.01) and MS characteristics. Conclusion. Antioxidative defense system is weakened and/or ineffective in patients with MS. Under such stress, keratinocyte synthesis is reduced, transepidermal water evaporation intensifies. These changes lead to skin barrier impairment, microbiota imbalance, fungal skin infections and papilloma development. Restoration of epidermal lipid layer of the skin is a particularly urgent task in patients with metabolic syndrome.