An experience for ELISA for desmoglein 1, suggesting a possible diagnostic help to determine the initial therapy for pemphigus foliaceus

Pemphigus is an autoimmune blistering disease characterized by the formation of numerous intraepidermal blisters covering extensive areas of the body. Major forms of pemphigus are pemphigus vulgaris and pemphigus foliaceus, in which loss of adhesion between keratinocytes (i.e., acantholysis) is mediated by the binding of autoantibodies against desmoglein (Dsg) 3 [1-3] and Dsg1 [4, 5], respectively. Pemphigus foliaceus is a disease that [...]