FeCl3-Mediated synthesis of polysubstituted tetrahydroquinolines via domino Mannich/Friedel–Crafts reactions of aldehydes and amines

A useful method to construct highly substituted tetrahydroquinolines has been developed through an iron(III) chloride-mediated domino Mannich and intramolecular Friedel–Crafts alkylation followed by intermolecular Friedel–Crafts alkylation reactions of aliphatic aldehydes with aromatic amines.