Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET

Oliver Goldhardt,Inanna Warnhoff,Igor Yakushev,Ilijana Begcevic,Hans Förstl,Viktor Magdolen,Antoninus Soosaipillai,Eleftherios P. Diamandis,Panagiotis Alexopoulos,Timo Grimmer

Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET

2019

Oliver Goldhardt
Inanna Warnhoff
Igor Yakushev
Ilijana Begcevic
Hans Förstl
Viktor Magdolen
Antoninus Soosaipillai
Eleftherios P. Diamandis
Panagiotis Alexopoulos
Timo Grimmer

Background Alterations in the expression of human kallikrein-related peptidases (KLKs) have been described in patients with Alzheimer’s disease (AD). We elucidated the suitability of KLK6, KLK8 and KLK10 to distinguish AD from NC and explored associations with established AD biomarkers.

Keywords:

Disease
Tau protein
Biomarker (medicine)
KLK6
Neurology
Cerebrospinal fluid
Pathology
KLK10
Medicine
Kallikrein
Positron emission tomography

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