Contribution of local field potential to subthalamic nucleus deep brain stimulation in Parkinson's disease

The subthalamic nucleus (STN) is the main target for deep brain stimulation (DBS) in Parkinson's disease. We analysed the relationships between magnetic resonance imaging (MRI) anatomy and electrophysiology done during surgery. In addition to extracellular recording of spontaneous neuronal activity (carried out conventionally in our Hospital), we performed simultaneous recordings of local field potential (LFP), i.e. deep EEG activity. We hypothesized that the contribution of LFP to neuronal firing rate with detailed MRI anatomy should allow to explore finely anatomo-electrophysiological relationships and also to determine precisely functional surgical targets.