Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.

Aims/hypothesis The Kruppel-like factor 11 (KLF11; TIEG2), a pancreas-enriched Sp1-like transcription factor, is a known negative regulator of pancreatic exocrine cell growth. A recent study indicated KLF11-induced activation of the human proinsulin promoter (hInsP).