Three new hopane-type triterpenoids from the aerial part of Adiantum capillus-veneris and their antimicrobial activities

Abstract Three new hopane-type triterpenoids ( 1 – 3 ), fern-7(8)-en-19α, 28-diol ( 1 ), pteron-14-ene-7α,19α,28-triol ( 2 ) and 3β,4α,25-trihydroxyfilican ( 3 ), were isolated from the aerial parts of Adiantum capillus-veneris . Their structures were determined by NMR spectroscopic and mass spectrometric data. Compounds 2 and 3 exhibited remarkable antifungal activity against Helminthosporium maydis and Alternaria alternata with MIC values of 12.5–3.125 μg/mL, and compound 3 also against Verticillium dahliae Kleb with an MIC value of 3.125 μg/mL. In addition, compounds 1 – 3 also displayed weak antibacterial activity against Micrococcus lysodeikticus, Bacterium paratyphosum B and Pseudomonas aeruginosa with an MIC value of 100 μg/mL.