SYNTHESIS AND SEROLOGICAL INTERACTIONS OF H.PYLORI UREASE FRAGMENT 321-339 N-TERMINALLY IMMOBILIZED ON THE CELLULOSE

3) Institute of Biology, awiItokrzyska Academy, awiItokrzyska 15, 25-406 Kielce, Poland Abstract: Antigenic epitopes F8 (SIKEDVQF) and UB-33 (UreB fragment with residues 321-339; CHHLDKSIKEDVQFADSRI) in H. pylori urease that induces neutralizing antibody production were prepared on the cellulose plate from N- to C-terminus using CDMT as a coupling reagent. Reaction of both epitopes with sera of patients with medically confirmed atherosclerosis was studied. Strong, selective reactions of both peptides with some patients sera were observed.