Reply to LTE: 11C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of Beta-Cell-Mass in Patients with Type-1 Diabetes.

REPLY: We would like to address several assumptions recently posited by Laffon and Marthan in their letter to the editor that was prompted by our recently published study examining the use of 11C-(+)-PHNO (3,4,4a,5,6,10b-hexahydro-2 H -naphtho\[1,2- b \]\[1,4\]oxazin-9-ol) to assess β-cell mass in