Development of photosensitizer-loaded lipid droplets for photothermal therapy based on thiophene analogs

Abstract A family of thiophene analogs was designed and synthesized as organic photothermal agents (PTAs). The specificity of the monitoring used for LDs is equally impressive. The feasibility that LDs-mediated photothermal ablation of tumor cells in vitro and in vivo was demonstrated. In general, the constructed photosensitizers can be used for photothermal therapy guided by lipid droplets imaging.