989. Toward Multivalent Adeno-Based Vaccine for Malaria: Effects of Promoter Strength on Immunogenicity and Vaccine Efficacy

Malaria is the most devastating parasitic disease affecting humans. Each year 300-500 million people become infected with the parasite and more than 1.5 million people, primarily children, die of the disease. The feasibility of a malaria vaccine is supported by the demonstration of protective immunity following exposure to the intact Plasmodium parasite.