296 The French clinical trials network: The National Platform for Clinical Research (NPCR)

Background In 2008, ECFS-CTN selected 6 multisite centres out of the 7 French inter-regions. Objectives The French CF Society (SFM) and the patients’ association setup (2009) a NPRC in order to optimize the contribution to Clinical Research (CR) of the 45 CF centres following 6200 patients recorded in the French CF Registry. Methods Establishment of i. a Steerco including the principal investigator and a clinical research coordinator (CRC) of each inter-region, SFM and patients’ association representatives; ii. a website, http://www.recherchecliniquemuco.fr/ ; iii. the CRC in each inter-region has the following main tasks: – collect/enter data related to patients’ inclusions into a software – run CR protocols within the multisite centres – assist the development of clinical studies – prepare investiqator's responses to CTN requests Results Advices by the Steerco for the setup of CR projects. The Webcast CR data show 31 industrial and 75 academic projects either carried out or in progress since 2010. Intervention of Steerco to setup a Vertex LEAD action for LCI training in France. Regular improvement in ECFS assessments of French multisite CTN centres. Conclusion The NPCR may help meet ECFS-CTN multisite centres challenges by: – giving an overview of CR projects – implementing tools for patient's screening and inclusion – sharing effective experiences of multisite centres – reinforcing the link between centres by greater involvement into a project regarding a priority topic (e.g. antibiotic treatment/LCI/physical activity) – identifying projects that have resulted in a publication and sometimes in a change in care practices – coordinating the ECFS eQUIP project deployment.