Polymorphism of CYP1A1 gene Msp I site in the Mongolian and Han nationality populations of Inner Mongolia of China

Objective To study the polymorphism of CYP1A1 gene Msp Ⅰ site in the Mongolian and Han nationality populations of Inner Mongolia. Methods The PCR-restriction fragment length polymorphism(PCR-RFLP) technique was used to analyze the genotypes of CYP1A1 gene MspⅠ site in 80 subjects of Mongolian nationality and 120 subjects of Han nationality, among whom there is no blood relationship each other. Results The genotype frequency of CYP1A1 gene MspⅠ site showed that the wild-type, heterozygote, homozygous variants were 35.0%, 48.7%, 16.3% and 33.3%, 52.5%, 14.2% respectively distributions of Mongolian nationality and Han nationality population, and the Chi-square tests showed that there was no significant difference between the two groups. Conclusion The genotype frequency distributions of CYP1A1 gene MspⅠ site did not exhibit the obvious difference between Mongolian nationality and Han nationality population of Inner Mongolia.[