The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer

Madhumitha Rengasamy,Fan Zhang,Ajay A. Vashisht,Won-Min Song,Francesca Aguilo,Yifei Sun,SiDe Li,Weijia Zhang,Bin Zhang,James A. Wohlschlegel,Martin J. Walsh

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer

2017

Madhumitha Rengasamy
Fan Zhang
Ajay A. Vashisht
Won-Min Song
Francesca Aguilo
Yifei Sun
SiDe Li
Weijia Zhang
Bin Zhang
James A. Wohlschlegel
Martin J. Walsh

We observed overexpression and increased intranuclear accumulation of the PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells. Utilizing mass spectrometry and b ...

Keywords:

Breast cancer
Exon
Protein arginine methyltransferase 5
RNA
RNA splicing
Molecular biology
Alternative splicing
Gene
Biology
Cell culture
Cancer research
Methylation

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