Facile access to chiral non-natural amino acids

Given the importance of enantioenriched β2- and β3-amino acids as building blocks, direct and versatile methods for their synthesis are highly coveted by organic chemists. Now, using easily accessible 1,3-oxazinane motifs, a regiodivergent and enantioselective C–H functionalization method permits their synthesis in a straightforward and practical fashion.