Bio- and Medicinally Compatible α-Amino-Acid Modification via Merging Photoredox and N-Heterocyclic Carbene Catalysis
2020
An N-heterocyclic
carbene and photoredox cocatalyzed α-amino-acid decarboxylative
carbonylation reaction is presented. This method displays good scope
generality, providing a direct pathway to access various downstream
α-amino ketones under bio- and medicinally compatible conditions.
Moreover, this strategy is appealing to chemical biology because it
has great potential for the chemical modification of peptides or the
late-stage synthesis of keto-peptides.
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