Effect of xuefu zhuyu decoction on the function of platelets and human umbilical vein endothelial cell

Objective: To explore the effect of Xuefu Zhuyu Decoction (XZD) on molecular expression of platelets glycoprotein II b/III a complex (GP II b/III a) and thrombomodulin (TM) of human umbilical vein endothelial cells.Methods: Platelets and human umbilical vein endothelial cells were incubated with XZD of different concentration. GP II b/III a and TM were evaluated by radioimmunoassay.Results: XZD in 40 mg/ml and 80 mg/ml could obviously inhibit the adenosine diphosphate induced GII b/III a complex expression, the molecular number being 52900 ± 8445 and 52095 ± 6345 respectively, and there was significant difference as comparing with that in the control group ( P < 0.05, P<0.01). But XZD didn’t show any influence on the molecular expression of TM in human umbilical vein endothelial cells.Conclusion: XZD could inhibit the adenosine diphosphate induced activation of platete through blocking the exposure of GII b/III a a complex.