Effect of combined BCG and UFT therapy of human maxillary cancer transplanted into nude mice

: Twenty male 5-6 week-old nude mice transplanted with human maxillary cancer (MC-Ya) were divided into 4 groups. Group I was treated with oral administration of 0.2 ml of 0.9% saline solution daily for 10-30 days, and served as control. Group II was treated with oral administration of 1 mg/mouse of BCG once a week for 10-30 days. Group III was treated with oral administration of 15 mg/kg of UFT daily for 10-30 days. Group IV was treated with the combination therapy of BCG and UFT. In comparison of the treatment effects in 4 groups, following results were obtained: 1) Mouse immunosuppressive acidic protein in the sera of nude mouse elevated in all groups, especially in group III. 2) The inhibitory effect on the growth of tumor was observed in group III and IV, especially in group IV, but not in group II. 3) The reason why the growth-inhibitory effect was observed more remarkably in group IV than in group III, would be explainable as the immunosuppression by UFT was restored by the immunostimulating effect of BCG.