Advances in the relationship between the detection of glypican-3 in serum and the diagnosis of primary hepatic carcinoma

Glypican-3(GPC3) was confirmed to be a novel tumor marker for hepatocellular carcinoma(HCC) besides alpha-fetoprotein(AFP). With the constant deepening of GPC3 research, it was found not only in tissues of patients with HCC but also in the serum. In the diagnosis of HCC, there were higher sensitivity and specificity, especially in the early stage, which had great value in clinical application, and bring new hope for the diagnosis of HCC.