Effect of ambroxol hydrochloride combined with phentolamine in adjuvant treatment of severe pneumonia in children

Objective To observe the effect of ambroxol hydrochloride combined with phentolamine in adjuvant treatment of severe pneumonia in children. Methods According to the digital table,93 children with severe pneumonia were selected and randomly divided into A group,B group and C group with 31 cases in each group. A group with conventional measures for treatment of severe pneumonia in children for treatment,B group based on treatment scheme of A group,with ambroxol hydrochloride injection intravenous infusion in group B, group C foundation treatment scheme,combined with phentolamine intravenous infusion.After 7d treatment in three groups were compared the clinical symptoms,signs and hospitalization days disappear, at the same time, the clinical effect between three groups of children and to observe the adverse reaction. Results In C group, the cooling time for(1.98±1.25)d,heart failure free period of(1.71±0.92)d,cough disappeared time of(2.90±1.08)d,rales disappearing for(6.22±1.13)d,the time of hospitalization for(6.42±1.57)d,were significantly lower than those of A group(t=4.55,4.72,4.38,4.59,5.12,all P<0.05)and B group(t=3.98,3.76,4.12,4.08,4.14,all P<0.05),B group of children with heart failure disappeared, antipyretic, cough disappeared,rales disappearing time was significantly lower than that in A group(t=3.97,4.01,3.88,3.56,all P<0.05);After treatment,in C group,the markedly effective rate was 41.94%,effective rate was 54.84%,total effective rate was 96.77%,which were significantly higher than those in A group and B group(χ2=10.33,5.165,all P<0.05);The three groups of children in the course of treatment were not serious adverse reactions. Conclusion Ambroxol hydrochloride injection combined with phentolamine injection can quickly control of children with severe pneumonia disease, improve the clinical efficacy in children with severe pneumonia,and less adverse reactions, which is worthy of popularization and application. Key words: Ambroxol hydrochloride injection; Phentolamine; Pneumonia