Effect of diabetes mellitus on markers of left ventricular dysfunction in chronic kidney disease

Abstract Objectives To identify markers of left ventricular dysfunction in chronic kidney disease (CKD) and the effects of diabetes mellitus on them. Methods This was a cross sectional study of 200 consecutive chronic kidney disease patients (stage III-V). Echocardiographic assessment of left ventricular function including left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI), left atrial volume, grade of diastolic dysfunction, E/E’, left and right ventricular myocardial performance indices (LVMPI, RVMPI) were compared between diabetic and non-diabetic CKD. Results LVMI significantly increased with increasing stage of CKD (p  Conclusion Advancing CKD stage was linearly associated with progressive left ventricular dysfunction which was significantly greater in diabetics.