Effect of oral aleurone supplementation on glucose and insulin dynamics of horses in training
2020
Aleurone is known to have positive effects on energy metabolism in pigs and
mice. Our aim was to study the effect of oral aleurone supplementation on
glucose and insulin dynamics in healthy trained horses in a cross-over training
trial. Sixteen Standardbred mares (3-4y) were trained for 2 periods of 8 weeks,
fed iso-energetic diets with and without 200 gr/day aleurone. A frequently
sampled intravenous glucose tolerance test (FSIGTT) and an oral glucose
tolerance test (OGTT) were executed before and after each training period. For
the OGTT outcome variables included: Maximumglucose, AUCglucose,
Maximuminsulin, AUCinsulin, and Time to peakinsulin; for the FSIGTT: acute
insulin response to glucose (AIRg), insulin sensitivity (SI), glucose effectiveness
(Sg) and disposition index (DI). Either a paired T-test was applied or a paired
Wilcoxon test. Training without aleurone induced significant OGTT variable
changes, which were not seen in the FSIGTT. OGTT Maximuminsulin was
significantly lower (P=0.005); Time to peakinsulin was higher (P=0.03) and
AUCinsulin was lower after training (P=0.001). Training with aleurone decreased
AIRg (P=0.03) and increased Sg (P=0.02). When comparing the FSIGTT
variables after training with aleurone to those after training without aleurone
AIRg was significantly lower in the aleurone fed group (P=0.004). Aleurone has a
beneficial effect on glucose and insulin dynamics on top of training in healthy
horses. This is attributable to increased tissue glucose uptake capacity. However,
more research is needed to elucidate the mode of action of aleurone at the level
of the skeletal muscle and the gut.
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