Estrogen Therapy in Men with Myocardial Infarction: Side-Effects with Increasing Dosage and Time

Long-term therapy with estrogens, in well-tolerated doses, was studied in men with myocardial infarction. This report indicates the feasibility of such studies. Of 109 men treated with estrogen for an aggregate of over 900 months, only 15 left the clinic for reasons other than death. Of these 15, 8 left before the appearance of any clinical manifestation of the estrogen therapy. The dosage schedule called for small initial doses and gradual increases until minor evidences were observed. Breast tenderness was the first finding in all but one patient. Long-term clinical studies of estrogen therapy in men, therefore, appear entirely feasible.