プラークアウト(R)の歯垢抑制効果の臨床的研究

1977 
The double blind test was performed to know the inhibitory effect for dental plaque and the clinical side effects of Plak-Out. Eighteen adults with healthy natural dentition, aged 22 to 27, were served as the subjects of this study.Scoring of plaque was restricted to six teeth (6/41|14/6). On each tooth, dental plaque was stained with 0.5% basic fuchsin and the height of plaque for gingival margin was measured. At the beginning of the study, these teeth were polished, and the use of oral hygiene device was stopped for 3 days. Plak-Out or Placebo was administered once a day for 3 days. Just before the administration, the accmulation of dental plaque was measured, and the clinical condition of whole mouth was observed. After four days, subjects were rediveded into two groups, and same procedures were performed. The subjects were applied Plak-Out or Placebe twice a day after ordinary tooth brushing and then the clinical side effects were observed every for three weeks.The results of this study were as follows:1) Plak-Out-liquid inhibited plaque accumulation than placebo statistically.2) Plak-Out-gel resulted in lower mean plaque scores than did the placebo-gel, but statistical differences (P<0.05) were found on the buccal surface and total accumulated plaque at 1st day.3) The discolouration of teeth occured in a few subjects, but no clinical side effect on the oral mucosa were found during the period of this study.
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