Esomeprazole one kind of freeze-dried powder and preparation method

The present invention discloses a freeze-dried powder of esomeprazole and its preparation method is the primary agent esomeprazole, adjuvants include protective agents, stabilizers and excipients, PH adjusting agent and water for injection by 1: 0.45 to 0.65: 0.25 to 0.5: 50 weight ratio of the formulation was placed in a stirred tank, stirred into an inert gas to accelerate foaming in a vacuum state, and then filtered through packaging, pre-freeze dried to give Esso omeprazole freeze-dried powder product. In the preparation process of the present invention, by using vacuum foaming techniques, a significant reduction in liquid water, the refrigeration drying time of only 50% of the conventional chemical processes, and the specific surface area of ​​the material after foaming significantly increased , pharmaceutical properties are significantly improved, the resulting finished powder injection volume bulky, difficult to agglomerate, good soluble complex, high clarity, not only has the advantage in heat resistance, and can be maintained after injection of the pharmacologically active agent, drug bioavailability is greatly improved.