Comparison o f C OAP a nd U W-19 Protocols f or Dogs with Multicentric L ymphoma

Results: There were 71 dogs in the COAP group and 30 dogs in the UW-19 group. Various protocols were used after the first relapse. The median duration of the first remission for the COAP and UW-19 groups were 94 days (range, 6–356 days) and 174 days (28–438 days), respectively (P , .01). The median survival times for dogs in the COAP and UW-19 groups were 309 days (6–620 days) and 275 days (70–1102+ days), respectively (P 5 .09). Dogs in the COAP group had a hazard ratio of 1.9 (95% CI 1.1–3.4) for death relative to the UW-19 group (P 5 .03), after controlling for the confounders (World Health Organization clinical stage, age, sex, use of doxorubicin during reinduction). The severity of neutropenia and gastrointestinal toxicoses were significantly higher in the UW-19 group than in the COAP group (P 5 .01 and P , .01, respectively). Conclusion and Clinical Importance: Use of a long-term doxorubicin-containing sequential combination chemotherapy protocol is associated with a decreased risk of relapse and death relative to a non-doxorubicin-containing protocol.