Efficacy Comparison on Moxifloxacin vs.Levofloxacin in the Treatment of Multi-drug Resistant Pulmonary Tuberculosis with Young and Middle-aged Patients

OBJECTIVE:To compare the clinical efficacy and saftey of moxifloxacin vs.levofloxacin in the treatment of multi-drug resistant pulmonary tuberculosis(MDR-PTB) with young and middle-aged patients.METHODS:The 76 young and middle-aged patients from Jun.2007 to Feb.2011 who received therapy on MDR-PTB in red cross hospital of Hangzhou as research subjects were divided into treatment group(40 cases) and control group(36 cases).Treatment group was given moxifloxacin(0.4 g/d,po)and control group was received levofloxacin(0.5 g/d,po).Both groups were treated with the same chemotherapy for 12 month.RESULTS:The effective rate(92.5%) and time of sputum negative conversion(87.5%) of treatment group was significantly higher than control group(75.0%,66.7%,P0.05).Adverse drug reaction rate between 2 groups were close,the difference was not significant(P0.05).CONCLUSIONS:Compared with levofloxacin,moxifloxacin combined with traditional method in the treatment of MDR-PTB has better clinical efficacy and sputum negative conversion,but lower adverse drug reaction.