Synthesis of new 4,5-substituted 4H-1,2,4-triazole-3-thiols and their sulfanyl derivatives

Reaction of hydrazides of 4-alkoxybenzoic acids with benzyl isothiocyanate followed by cyclization with thiosemicarbazide afforded a series of new 4,5-substituted 4H-1,2,4-triazole-3-thiols. S-Alkylation of the latter led to the formation of the corresponding 4,5-substituted sulfanyl derivatives of 4H-1,2,4-triazoles.