Experimental Research of Lei Zhu Sun′s Juice on the Preventing Diabetic Effect

Objective To observe the preventive effects of Lei Zhu Sun′s juice (LZS) on the diabetes mellitus.Methods The rats were randomly divided into three groups:① normal control (n=8),② models after premedication with normal saline (n=12),③ models after premedication with low dosage of LZS (n=12) and ④ models after premedication with high dosage of LZS (n=12).The premedications were continued for 28 days,and then the rats of latter three groups were all made into diabetic models by using the alloxan.The contents of glucose (Glu),tri acylglycerol (TG),non esterified fatty acid (NEFA),total cholesterol (TC),low density lipoprotein cholesterol (LDL c),high density lipoprotein cholesterol (HDL c) and malondialdehyde (MDA) and the superoxide dismutase(SOD) activity in plasma and the contents of hepatic glycogen (HG) of all rats were measured.Results The contents of Glu,TG,NEFA,TC,LDL C and MDA in diabetic rats with premedication of LZS were obviously lower than that of control diabetic model group (P0.05～0.01),whereas the contents of HDL c,HG and SOD activities in plasma of the rats of LZS groups were more higher than that of control group (P0.01).The inhibiting effect of LZS on the increasing contents of TC and LDL c had obvious dose effect relationship (P0.01).Conclusion LZS has an effect to preventing diabetes mellitus.