Elevated plasma levels of soluble C-type lectin-like receptor 2 (CLEC2) in patients with thrombotic microangiopathy

Abstract Background Thrombotic microangiopathy (TMA) is caused by activated platelets. The plasma C-type lectin-like receptor 2 (CLEC2) levels in 58 patients with TMA were examined and compared with those in healthy volunteers and other diseases. Materials and methods The plasma levels of soluble platelet surface glycoprotein VI (GPVI) and CLEC2 were measured in patients with TMA. Results Plasma CLEC2 levels in patients with DIC and TMA were significantly higher ( p p p Conclusion The measurement of the plasma CLEC2 level is considered to be important for the diagnosis and evaluation of TMA.