METHOD FOR PRODUCING α-FLUORO-β-AMINO ACID COMPOUNDS

PROBLEM TO BE SOLVED: To provide a method for commercially producing an α-fluoro-β-amino acid compound. SOLUTION: Provided is a method for producing an α-fluoro-β-amino acid compound, which comprises reacting a β-hydroxy-α-amino acid compound with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base. When an 8 to 12C tertiary amine compound having two or more ≥3C alkyl groups, especially diisopropylethylamine, is used as the organic base, the by-production of a quaternary ammonium salt can effectively be prevented. Methyl (2R)-3-(dibenzylamino)-2-fluoropropionate extremely important as an intermediate for medicines can industrially remarkably easily be produced in high position selectivity. COPYRIGHT: (C)2010,JPO&INPIT