One kind of the method of producing vitamin b1 thiamine hydrochloride thiol

BACKGROUND applied to one kind of medicine by the method of preparing vitamin B1 thiamine hydrochloride thiol, vitamin B1 thiamine intermediate thiol as a raw material, the process comprising the steps of: after the hydrogen peroxide oxidation of thiol sulfur after dilution with purified water with an appropriate amount of the amine solution through a cation exchange resin column and exchanging dissociation; exchange resin column was washed with purified water q.s. cation, washed until washings were added to the content of a few drops of 5% barium chloride solution, invisible until the white precipitate of barium sulfate; cationic resin exchange column eluted with an eluent, until the effluent was no longer following vitamin Bl; said cation exchange resin is a strongly acidic cation exchange resin 732 thereof; the the cation exchange resin used in an amount of 1-6 times the total mass of the thiol thiamine; eluent said content of 5 to 20% diluted hydrochloric acid. The invention generates no impurity ions, green, mild reaction conditions, rapid reaction rate, high conversion and selectivity and long life of the catalyst cation exchange resin is easily recycled.