N-substituted heterocyclic derivative, its preparation and pharmaceutic composition

PURPOSE: To provide a new N-substd. heterocyclic deriv. which inhibits the effects of angiotensin II and is useful for the treatment for cardiovascular disorders, central nervous system disorders and the like. CONSTITUTION: The compd. is expressed by formula I, wherein R 1 and R 2 are each alkyl, cycloalkyl, phenyl, phenylalkyl, or bonded to form CR 1 ', R 2 ' (R 1 ' is H, alkyl, phenyl; R 2 ' is alkyl, phenyl), (CH 2 ) n ((n) is 2 to 11), etc.; R 3 is H, (halogen-substd.) alkyl, alkenyl, cycloalkyl, phenyl, etc.; R 4 is expressed by formulae II to IV, etc.; R 6 and R 6 ' are each H, carboxy, alkoxycarbonyl, CN, 5-tetrazolyl, etc.; R 6 " is H, Cl, alkyl, amino, etc.; R 7 is alkyl, (CH 2 ) γ -CO 2 H, formula V, etc.; R 8 is R 4 , H, halogen, etc.; R 9 is H, R 8 (but not same); (γ) is 0 to 2; X is O, S; Z, t are both 0 or one of these is 1. The compd. with X being O is obtd. by the reaction of a compd. expressed by formula VI with a compd. expressed by Hal-R 4 ' (R 4 ' is R 4 or its precursor). COPYRIGHT: (C)1993,JPO