Homeostasis disorders in chronic hypoxia in pregnant women with heart defects

Central hemodynamics, free-radical lipid oxidation, anti-oxidant system, activities of lysosomal enzymes, and homeostasis system were studied in 86 pregnant women with congenital and acquired heart diseases. The studies have revealed a hypodynamic circulation type, activated lipid peroxidation processes, reduced level of alpha-tocopherol, a natural antioxidant, and activated coagulating and depressed anticoagulating system of the blood. These pathologic processes results in development of a mixed form of chronic hypoxia, augmenting with the progress of the heart condition. Assessment of these parameters helps timely start differentiated intensive care and improve labor outcome for the mother and fetus.