Hydration effects on Leu's polyproline II population in AcLXPNH2

Hydration is important in many fundamental processes. To investigate hydration effects on peptide conformations, we examined neighboring-residue and side-chain blocking effects in AcLXPNH2. A correlation between two effects suggests that hydration stabilizes PII more than β-structures. Our results are important for understanding the hydration effects on peptide conformations and hydration-forces in general.