Pencil graphite electrode based electrochemical system for the investigation of antihypertensive drug hydrochlorothiazide: An electrochemical study

Abstract A Trypan Blue modified combined pencil graphite electrode system (TyB-GGG) has been employed for the electrochemical investigation of Hydrochlorothiazide (HTZ). The linear calibration curves were obtained in the concentration range of 0.5–7 µM (for DPV) and 0.1–5 µM (for SWV), respectively. The detection limits were found to be 0.1327 µM and 0.0320 µM, respectively. The electrodes resistance has been studied using electrochemical impedance spectroscopy (EIS). The modified electrode TyB-GGG has been successfully employed for the determination of HTZ present in pharmaceutical sample.