Massive prosthetic valve thrombus in a patient with idiopathic hypereosinophilic syndrome

o a o M o a f o i DIOPATHIC HYPEREOSINOPHILIC syndrome (HES) is a rare systemic disease characterized by unexplained persisent eosinophilia associated with multiple-organ damage. It is hought that inflammation mediated by eosinophils and micromboli cause organ damage.1 The prognosis is correlated with ardiac damage, which includes restrictive cardiomyopathy, alvular dysfunction, and thromboembolic events.2,3 Although ome cases of recurrent prosthetic valve thromboses have been eported,4,5 experience in the perioperative management of ardiac valvular surgery in patients with HES is limited.6,7 In this report, 2 patients with HES undergoing cardiac surery are described. One of them developed severe prosthetic alve insufficiency and died. The authors also review the litrature with regard to the perioperative management of patients ith HES.