Iridoid glycosides from Harpagophytum procumbens D.C. (devil’s claw)

Iridoid glycosides, harprocumbide A (6"-O-alpha-D-galactopyranosyl harpagoside, 1) and harprocumbide B (6"-O-(cis p-coumaroyl)-procumbide, 2) were isolated from the tubers of Harpagophytum prucumbens D.C., along with nine known iridoid glycosides 6-O-alpha-D-galactopyranosylharpagoside (3), and harpagoside (4), harpagide (5), 8-cinnamoylmyoporoside (6), 8-O-feruloylhapagide (7), procumbide (8), 6"-O-(p-coumaroyl)-procumbide (9), 8-O-(p-coumaroyl)-harpagide (10) and 8-O-(cis p-coumaroyl)-harpagide (11). Compound 10 showed marginal inhibition activity against macrophages respiratory burst. (c) 2006 Elsevier Ltd. All rights reserved.