Variability in quantitative diffusion-weighted MR imaging (DWI) across different scanners and imaging sites: is there a potential consensus that can help reducing the limits of expected bias?

Key Points • Variability of ADC measurements may be substantial across different MRI scanners and imaging sites. • DWI protocol standardization and increased awareness of frequent sources of error can help reducing the limits of expected bias. • Focusing on ADC change and normalized ADC values rather than on absolute measurements can facilitate consistent use of ADC in multi-center studies.