Effect of shensong yangxin capsule on ventricular premature beat and cardiovascular autonomic nervous function in patients with coronary heart disease

ObjectiveTo observe the clinical efficacy of Shensong Yangxin capsule (SYC) on ventricular premature beat (VPB) differentiated in TCM as palpitation of Qi-yin deficiency syndrome or Xin collateral stagnation syndrome, and cardiovascular autonomic nervous function in patients with coronary heart disease (CHD). MethodsThe randomized, double-blind, parallel contrast method was adopted, patients were randomly assigned by 3∶1 ratio into two groups. One hundred and sixty-five patients in SYC treated group and 56 in the control group(treated with Xinlvning tablet), and the therapeutic course for both groups was 4 weeks. ResultsThe clinical efficacy on VPB and in improving TCM syndromes was better in SYC group than that in the control group (P0.01). After treatment, the heart rate variability (HRV) and QT dispersion in the two groups were improved in a certain degree. The changes of SDNN, SDANN, SDNN Index and PNN 50 in the two groups were significantly different (P0.05,P0.01), the efficacy in the treated group was superior to that in the control group. ConclusionSYC has definite effect on VPB and TCM Syndromes, it can obviously meliorate the activity of cardiovascular autonomic nervous system in the patients with CHD.