Effect of metoclopramide on ketoprofen pharmacokinetics in man

Abstract The effect of oral administration of metoclopramide (10 mg) on the absorption of ketoprofen from a capsule dosage form (50 mg) was studied in four healthy subjects in a cross-over design. The plasma concentrations of ketoprofen were determined by a HPLC technique. The results demonstrated a marked decrease in drug levels during coadministration with metoclopramide in the first 2 h post-dose. Metoclopramide resulted in markedly lower AUC and C max values with a longer T max of ketoprofen in comparison with the corresponding values for the drug alone. The results suggest that the gastric phase of ketoprofen absorption is the determinant step of the process. Rapid transit of the capsule, due to metoclopramide, reduces the time required for adequate dissolution and absorption.