Abstract 3566: Confirmed Influence Of The LPIN1 Gene On Traits Of The Metabolic Syndrome In Human

Lipin, a molecular protein expressed by adipocytes, has marked effects on adipose tissue mass, insulin sensitivity, and glucose homeostasis. Genetic variants within the lipin gene, LPIN1, may be associated with traits of the metabolic syndrome (MetS) as we have shown previously in a sample of the general population. Methods: 15 SNPs densely covering the LPIN1 gene region were genotyped in an age- and sex- stratified sample of the general population (MONICA study Augsburg, DNA and phenotypes of 1,416 Caucasians). Ten of these SNPs were also genotyped for replication in an independent sample of 1,030 subjects recruited throughout Germany. The MetS was defined via the sum of its core components and additionally by a factor score derived from factor analysis. Permutation based methods were used to test the association between genetic LPIN1 variants and metabolic traits for empirical significance. Results: Linkage disequilibrium (LD) analysis revealed three LD blocks encompassing LPIN1. We identified three ass...