[Clinical experience of vaginal contraceptive film containing the spermicide, polyoxyethylene nonylphenyl ether (c-film study group) (authors' transl)].

A new vaginal contraceptive in the form of a film containing the spermicide polyoxyethylene nonylphenyl ether (C-Film) was put into clinical trials. To evaluate spermicidal activity of C-film an in vitro test was performed. After 1 minute no motile sperm could be seen in the C-film solution which was diluted 32 times by a 5% glucose solution. When the sperm contacted the C-film solution diluted 8 times the sperm stopped moving. C-film was used by 168 women for 1 and one-half years from December 1977 to May 1979 for a total period of 2161 months. Only 1 pregnancy occurred thus giving a pregnancy rate of 0.56/100 women-years. During the use of C-film 16 cases (9.5%) complained about an increase of vaginal discharge 8 cases (4.8%) felt unfamiliar with the insertion and 7 cases (4.2%) complained about unusual feelings caused by the presence of the C-film. A total of 9 cases (5.4%) stopped using C-film; 3 due to irritation 2 due to troublesome use; and others due to vaginal discharge burning sensation pregnancy and reasons unknown. No significant changes were observed in the vaginal bacteriology cervical cytology liver function or renal function. The study indicates that C-film is very effective well-tolerated and has a low incidence of side effects. (Authors modified) (Summary in ENG)