Synthesis of β-lactams via Staudinger reaction using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline as a carboxylic acid activator
2016
ABSTRACTN-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) has been used as an efficient and convenient reagent for the one-pot synthesis of β-lactams by [2+2] ketene–imine cycloaddition (Staudinger reaction). Cleanliness, simplicity of method, and good to excellent yields of products are some advantages of this method.
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