A method of redoxometry in clinical studies

: Direct estimation of redox-potential in human skin and muscles using platinum electrodes enables to carry out dynamic evaluations of redox-state in these tissues. A similar technique might be used for potentiometric measurement of the rate of local tissue circulation using hydrogen clearance. Increase in the electrodes sensitivity, required for studies of circulation severe impairments, was possible by means of additional platinum overlaying. Examination of patients with obliterating atherosclerosis showed a considerable decrease of redox-potential in ischemic zone; this impairment was partially reduced after surgical operation. The validity of alterations in electrode potential was supported by means of oxygenometry, blood pH-metry and rates of tissue circulation measurements. Interpretation of the data obtained is limited due to requirements of obligatory functional loading and theoretical considerations. However, the procedure of electrode potential registration allowed to obtain an information essential for choice of suitable treatment course.